|
|
|
|
|
|
Cellular and Molecular Gastroenterology and Hepatology
Volume 11 (5), 2021, Pages 1463-1482
|
Regulation of Intestinal Barrier Function by Microbial Metabolites
Sweta Ghosh, Caleb Samuel, Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky.
Abstract
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that continually shapes host pathophysiological responses. Despite readily available abundant metagenomic data, the functional dynamics of gut microbiota remain to be explored in various health and disease conditions. Microbiota generate a variety of metabolites from dietary products that influence host health and pathophysiological functions. Since gut microbial metabolites are produced in close proximity to gut epithelium, presumably they have significant impact on gut barrier function and immune responses. The goal of this review is to discuss recent advances on gut microbial metabolites in the regulation of intestinal barrier function. While the mechanisms of action of these metabolites are only beginning to emerge, they mainly point to a small group of shared pathways that control gut barrier functions. Amidst expanding technology and broadening knowledge, exploitation of beneficial microbiota and their metabolites to restore pathophysiological balance will likely prove to be an extremely useful remedial tool.
Keywords: Microbiota, Microbial Metabolites, Gut Barrier Function, Tight Junction Proteins, Permeability.
| |
|
|
|
Copyright
© 2005 ENVIS Centre ! All rights reserved |
This
site is optimized for 1024 x 768 screen resolution |
|
|
Environmental Information System (ENVIS) provides national and international
environmental information in the disciplines of pollution control,microorganisms,envis,
toxic chemicals, central and offshore ecology, environmentally sound and appropriate
technology, bio-degradation of wastes and environment management.
microorganims,envis,environment information system centre, microorganisms
and environment management, environment management, microorganisms, microbes
Environment Information System Centre - microorganims,envis,environment
management, microorganisms, microbes, pollution control, toxic chemicals,
central and offshore ecology, environmentally sound and appropriate technology,
bio-degradation of wastes.